Cereprotex displayed a significant anti-edema effect in a model of closed head injury.

Cereprotex displayed a significant anti-edema effect in a model of closed head injury. It significant decreases in the degree of edema developed after injury was found following treatment postponed one hour after traumatic injury. About 35% less water accumulated in the traumatized hemisphere of the Cereprotex (Patent pending – Cereprotec Inc. www.cereprotec.com ) treated mice, as compared with vehicle-treated animals. Water content in the contralateral hemisphere reverted to normal levels.

Cereprotex has impressive antihypoxic effect in hypercapnic normobaric model of hypoxia; it prolonged significantly convulsion latency at 84% and survival time of mice at 78,4%. Cereprotex exerted a dose dependent antihypoxic effect in hypobaric hypoxia in rats. Doses of 100, 250 and 500 mg/kg exhibited significantly increasing survival time by162%, 275%, and 425%, respectively, as compared to control group, in a model of hypoxia.